hosted by GitHub

Morpheus is a database search algorithm designed from the ground up for high-resolution tandem mass spectra. We have discovered that for high-resolution MS/MS, simple spectrum preprocessing and scoring performs superior to more complex algorithms originally developed for low-resolution MS/MS, such as Sequest, Mascot, and OMSSA. Morpheus is also very fast—up to nearly 5 times faster than OMSSA for large human datasets. It is written in C# and is available open source under the permissive MIT License.

GitHub Project Page



View all releases
View latest release
Linux / Mac OS X

Source Code

Morpheus is available as Visual Studio and MonoDevelop projects. Morpheus uses the Git version control system. The repository URL is . You can also browse the code online at

Supporting Data



Morpheus is free and open-source software released under the permissive MIT License.

Frequently Asked Questions (FAQ)

Command-Line Arguments