Morpheus is a database search algorithm designed from the ground up for high-resolution tandem mass spectra. We have discovered that for high-resolution MS/MS, simple spectrum preprocessing and scoring performs superior to more complex algorithms originally developed for low-resolution MS/MS, such as Sequest, Mascot, and OMSSA. Morpheus is also very fast—up to nearly 5 times faster than OMSSA for large human datasets. It is written in C# and is available open source under the permissive MIT License.
|Linux / Mac OS X|
Morpheus is available as Visual Studio and MonoDevelop projects. Morpheus uses the Git version control system. The repository URL is https://github.com/cwenger/Morpheus.git . You can also browse the code online at https://github.com/cwenger/Morpheus.
Shortreed, Michael R.; Wenger, Craig D.; Frey, Brian L.; Sheynkman, Gloria M.; Scalf, Mark; Keller, Mark P.; Attie, Alan D.; Smith, Lloyd M.: "Global Identification of Protein Post-translational Modifications in a Single-Pass Database Search", Journal of Proteome Research 14(11):4714–4720 (2015)
Morpheus is free and open-source software released under the permissive MIT License.